News


Nov 18, 2022
Our work uniPort was accepted by Nature Communications, and selected as Editor's Highlight.

Nov 14, 2022
I joined Caroline Uhler lab at Broad Institute of MIT and Harvard as a Postdoctoral Researcher.

May 22, 2022
I passed the PhD thesis defense.

Nov 1, 2021
I was honored with the China National Scholarship for doctoral students.

Aug 10, 2021
Our work Pamona was accepted by Bioinformatics.

Mar 13, 2020
Our work UnionCom was accepted by ISMB Conference.

Kai Cao 

Eric and Wendy Schmidt Center
Klarman Cell Observatory
Broad Institute of MIT and Harvard

415 Main Street, Cambridge, MA, USA, 02142

Email: caokai1073@gmail.com
GitHub     • Google Scholar

I am a Postdoc Fellow at the Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, working with Prof. Caroline Uhler and Prof. Ramnik Xavier. My research aims to bridge machine learning and biology, focusing on developing computational methods to tackle unresolved biological problems.

Education

Chinese Academy of Sciences
Ph.D. in System Science, Academy of Mathematics and Systems Science, Beijing, China
Sep 2017 - Jun 2022
Advisor: Prof. Lin Wan, Prof. Yiguang Hong
University of Science and Technology of China
Bachelor in Automation, School of Information Science and Technology, Hefei, Anhui, China
Sep 2013 - June 2017
Advisor: Prof. Weiwei Shang

Experiences

Postdoctoral Associate, Broad Institute of MIT and Harvard, United States
Nov 2022 - Present
Advisor: Prof. Caroline Uhler & Prof. Ramnik Xavier
Research Assistant, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, China
Sep 2018 - June 2022
Mentor: Prof. Lin Wan & Prof. Yiguang Hong
Visiting Scholar, Department of Electrical and Computer Engineering, University of Newcastle, Australia
June 2016 - Sep 2016
Mentor: Prof. Zhiyong Chen

Publications



pdf
Graspot: A graph attention network for spatial transcriptomics data integration with optimal transport
Zizhan Gao, Kai Cao#, Lin Wan# (#co-corresponding)
BioRxiv, 2024   

pdf
SONATA: Disambiguated manifold alignment of single-cell data
Han Zhou, Kai Cao, Yang Lu
BioRxiv, 2023   

pdf
A unified framework for single-cell data integration with optimal transport
Kai Cao*, Qiyu Gong*, Yiguang Hong & Lin Wan (*co-first)
Nature Communications, 2022 (Editors’ Highlights)    Codes   

pdf
Manifold alignment for heterogeneous single-cell multi-omics data integration using Pamona
Kai Cao, Yiguang Hong & Lin Wan
Bioinformatics, 2021    Codes   

pdf
Unsupervised Topological Alignment for Single-Cell Multi-Omics Integration
Kai Cao, Xiangqi Bai, Yiguang Hong & Lin Wan
Bioinformatics, 2020 (ISMB oral presentation, accept rate: 19%)    Codes   

pdf
Class conditional distribution alignment for domain adaptation
Kai Cao, Zhipeng Tu & Yang Ming
Control Theory and Technology, 2020   

pdf
Learning implicit information in Bayesian games with knowledge transfer
Guangpu Chen, Kai Cao & Yiguang Hong
Control Theory and Technology, 2020   

pdf
Continuous-time distributed algorithms for solving linear algebraic equation
Kai Cao, Xianlin Zeng & Yiguang Hong
Proceeding of the 36th Chinese Control Conference (CCC), 2017   

pdf
Computation of linear algebraic equations with solvability verification over multi-agent networks
X. Zeng & K. Cao
Kybernetika, 2017   

Presentations

Models, Inference & Algorithms (MIA), 2024
Title: Single-cell Multi-omics Data Integration with Optimal Transport
The 1st Chinese Intelligent Health & Bioinformatics Conference, 2022
Title: Single-cell Multi-omics Data Integration with Optimal Transport
The 28th Conference on Intelligent Systems for Molecular Biology (ISMB), 2020
Title: Unsupervised Topological Alignment for Single-Cell Multi-Omics Integration

Awards

EWSC Postdoctoral Fellowship, Broad Institute of MIT and Harvard, 2022
China National Scholarship for doctoral students, 2021
Merit Student of University of Chinese Academy of Sciences, 2020
China National Scholarship for Encouragement, 2016
Outstanding Undergraduate Research Program Award, 2016
Individual Scholarship of USTC, 2014

Academic Services

Journal reviewer of Advanced Science, Bioinformatics Advances, PLOS Computational Biology.
Conference reviewer of ISMB, RECOMB.

Last update: April 18th, 2024. Webpage template borrows from Jiancan Wu.